Lentiviral vector-mediated gene transfer and uses thereof

Details Lentiviral vector-mediated gene transfer and uses thereof Lentiviral vector-mediated gene transfer and uses thereof

A - Human Necessities

61

K

A61K 35/00 (2006.01) A61K 48/00 (2006.01) C12N 15/63 (2006.01) C12N 15/867 (2006.01)

Patent

CA 2499643

The present invention provides lentiviral vectors that are useful in human gene therapy for inherited or acquired proliferative ocular disease. It furnishes methods to exploit the ability of lentiviral vectors to transduce both mitotically active and inactive cells so that eye diseases may be treated.

La présente invention concerne des vecteurs lentiviraux utilisés en thérapie génique humaine destinée à une maladie occulaire proliférative acquise ou héritée. Cette invention a aussi trait à des méthodes d'exploitation de la capacité des vecteurs lentiviraux à tansduire des cellules actives et inactives au niveau mitotique, de telle manière que des maladies des yeux peuvent être traitées.

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