Lentiviral vector transduction of hematopoietic stem cells

Details Lentiviral vector transduction of hematopoietic stem cells Lentiviral vector transduction of hematopoietic stem cells

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 35/00 (2006.01) A61K 48/00 (2006.01) C07H 21/04 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01) C12N 15/867 (2006.01)

Patent

CA 2391129

Disclosed are compositions and methods for making and using these compositions that are related to the transduction of hematopoietic stem cells. Disclosed are lentiviral vectors capable of transducing purified populations of hematopoietic stem cells. The compositions and methods can be used for treating diseases related to blood disorders such as sickle cell and thalassemia.

L'invention concerne des compositions et des procédés de préparation et d'utilisation de ces compositions en rapport avec la transduction de cellules souches hématopoïétiques. Elle concerne des vecteurs de lentivirus capables d'effectuer la transduction de populations purifiées de cellules souches hématopoïétiques. On peut mettre en application ces compositions et ces procédés afin de traiter des maladies présentant des troubles sanguins, telles que la drépanocytose ou la thalassémie.

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