C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) A61K 35/76 (2006.01) C12N 5/10 (2006.01) C12N 7/00 (2006.01) C12N 15/49 (2006.01) C12N 15/867 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2268271
Retroviral vector particles capable of infecting and transducing non-dividing mammalian target cells, which vector particles may be based on lentiviruses such as HIV and which have an RNA genome constructed so as to provide in the DNA provirus a non-lentiviral expression control element in the 5'LTR of the provirus.
La présente invention concerne des particules de vecteurs lentiviraux capables d'infecter et de transduire des cellules-cibles mamméliennes non divisibles dont les particules de vecteurs peuvent dériver de lentivirus tels que le VIH et qui possèdent un ARN génomique construit de telle manière à fournir au provirus de l'ADN un élément de contrôle sur l'expression non lentivirale au niveau de la 5'LTR du provirus.
Kingsman Alan John
Kingsman Susan Mary
Gowling Lafleur Henderson Llp
Oxford Biomedica (uk) Limited
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