Lentiviral vectors and their use

Details Lentiviral vectors and their use Lentiviral vectors and their use

C - Chemistry, Metallurgy

12

N

C12N 15/867 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) A61P 37/06 (2006.01) C12N 15/85 (2006.01) C07K 14/11 (2006.01) C12N 9/24 (2006.01)

Patent

CA 2597928

The present invention relates to lentiviral vectors for gene therapy, cancer treatment, producing recombinant proteins, such as antibodies and vaccines, and other therapeutic purposes. Novel lentiviral vectors are disclosed, e.g., comprising helper sequences in opposite orientations and/or minimally functional LTR sequences, which can be used to prepare high efficiency transduction vectors. Vectors are also designed to express silencing RNA and antisense polynucleotides.

L'invention concerne des vecteurs lentiviraux pour la thérapie génique, le traitement du cancer, la production de protéines recombinantes, telles que les anticorps et les vaccins et d'autres applications thérapeutiques. Des vecteurs antiviraux nouveaux, dont, entre autres, des séquences auxiliaires dans des séquences LTR à fonctionnalité minimale et/ou orientations opposées, qui peuvent être utilisés pour la préparation de vecteurs de transduction de grande efficacité, sont décrits. Des vecteurs sont également conçus pour exprimer le silençage de l'ARN et des polynucléotides antisens.

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