A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 39/21 (2006.01)
Patent
CA 2537953
The present invention relates to multiple novel approaches for the generation of an immune response in humans using lentivirus-based vector technology. The invention provides for the ability to mimic the efficacy of a live attenuated (LA) vaccine, without exposing the patient to the risk of disease as possible with some LA vaccines. The invention thus provides for systems of complementary conditionally replicating vectors, vectors that produce replication deficient virus like particles, and multi-antigen constructs that target a virus or microbial pathogen. The use of these materials in the practice of the invention permits the generation of robust cellular and humoral responses to the antigens presented thereby.
L'invention concerne de multiples nouvelles approches permettant de générer une réponse immunitaire chez des humains à l'aide d'une technologie de vecteurs à base de lentivirus. L'invention permet de mimer l'efficacité d'un vaccin vivant atténué (LA) sans exposer le patient à un risque de maladie comme cela est possible avec certains vaccins LA. L'invention concerne également des systèmes de vecteurs de réplication conditionnelle complémentaire, des vecteurs produisant des particules du type virus à déficience de réplication et des multi-antigènes ciblant un virus ou un pathogène microbien. L'utilisation de ces matériaux dans la pratique de l'invention permet de générer des réponses cellulaires et humorales robustes aux antigènes précités.
Dropulic Boro
Lu Xiaobin
Fetherstonhaugh & Co.
Virxsys Corporation
LandOfFree
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