Leptin and leptin analog conjugates and uses thereof

Details Leptin and leptin analog conjugates and uses thereof Leptin and leptin analog conjugates and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 38/22 (2006.01) A61K 47/48 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) C07K 7/08 (2006.01) C07K 14/575 (2006.01) C07K 14/81 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2745527

The present invention features a compound having the formula A-X-B, where A is peptide vector capable of enhancing transport of the compound across the blood- brain barrier or into particular cell types, X is a linker, and B is a leptin, a leptin analog, or OB receptor agonist. The compounds of the invention can be used to treat any disease in which increased amounts of leptin are desired, such as metabolic diseases including obesity and diabetes.

La présente invention concerne un composé de formule A-X-B, où A est un vecteur peptidique pouvant améliorer le transport du composé à travers la barrière sang-cerveau ou dans des types de cellules particuliers, X est un pont et B est une leptine, un analogue de leptine ou un agoniste de récepteur OB. Les composés selon l'invention peuvent être employés dans le traitement de toute pathologie améliorée par l'augmentation de la teneur en leptine, par exemple les pathologies métaboliques, y compris l'obésité et le diabète.

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