Leptin promoter polymorphisms and uses thereof

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01) C07H 21/04 (2006.01)

Patent

CA 2556911

The present invention relates to single nucleotide polymorphisms (SNPs) in the leptin promoter, and to methods for the identification of animals carrying specific alleles of these SNPs that are associated with circulating leptin levels, feed intake, growth rate, body weight, carcass merit and carcass composition. The present invention provides oligonucleotides that can be used as primers and/or probes to amplify and/or detect these SNPs, and provides methods for selecting and grouping animals, in particular bovines, according to genotype.

La présente invention se rapporte à des polymorphismes nucléotidiques simples (SNP) présents dans le promoteur de la leptine, ainsi qu'à des procédés permettant l'identification d'animaux portant des allèles spécifiques de ces SNP qui sont associés à des valeurs données de taux de leptine circulante, de prise alimentaire, de taux de croissance, de poids corporel, de valeur de carcasse et de composition de carcasse. La présente invention se rapporte à des oligonucléotides qui peuvent être utilisés en tant qu'amorces et/ou sondes pour amplifier et/ou détecter ces SNP, ainsi qu'à des procédés de sélection et de groupage d'animaux, notamment de bovins, conformément à un génotype.

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