A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07D 309/32 (2006.01)
Patent
CA 2654322
Leptomycin derivatives having a moiety, such as a sulfide or a disulfide, that can conjugate to a cell binding reagent such as an antibody are disclosed. The therapeutic use of such leptomycin derivative conjugates is also described; such conjugates have therapeutic use because they can deliver cytotoxic leptomycin derivatives to a specific cell population in a targeted fashion.
La présente invention concerne des dérivés de leptomycine comportant un groupement, tel qu'un sulfure ou un disulfure, qui peuvent être des conjugués d'un réactif de liaison cellulaire tel qu'un anticorps. L'invention concerne également la thérapeutique qui utilise de tels conjugués dérivés de leptomycine. Lesdits conjugués peuvent avoir un usage thérapeutique car ils sont susceptibles de libérer des dérivés de leptomycine cytotoxiques dans une population cellulaire spécifique selon un mode ciblé.
Bouchard Herve
Chari Ravi V.j.
Commercon Alain
Robic
Sanofi-Aventis
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