Leptospira membrane proteins

Details Leptospira membrane proteins Leptospira membrane proteins

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 39/02 (2006.01) C07K 14/20 (2006.01) C07K 16/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2220674

The present invention presents novel leptospiral membrane lipoproteins, LipL1 and LipL2, associated with pathogenic strains of Leptospira. LipL1 is of about 35 kDa, and LipL2 is of about 41 kDa. Also disclosed are the method for purifying these proteins from Leptospira, their nucleotide and amino acid sequences, the cloning of the genes encoding the proteins and their recombinant proteins, methods for producing antibodies to these proteins, the resulting antibodies. These proteins, their immunogenic fragments, and antibodies against them, are useful for inducing an immune response to pathogenic Leptospira as well as providing a diagnostic target for leptospirosis.

Cette invention concerne de nouvelles lipoprotéines membranaires leptospirales, Lip1 et LipL2, associées à des souches pathogènes de Leptospira. LipL1 et LipL2 sont respectivement des lipoprotéines d'environ 35 kDa et d'environ 41 kDa. On décrit également le procédé de purification de ces protéines à partir de Leptospira, leurs séquences nucléotidiques et d'acides aminés, le clonage des gènes codant les protéines et leurs protéines de recombinaison, des procédés de production d'anticorps contre ces protéines et les anticorps résultants. On utilise ces protéines, leurs fragments immunogènes et les anticorps dirigés contre ces protéines pour induire une réponse immune contre la Leptospira pathogène et pour produire une cible de diagnostic contre la leptospirose.

Affiliated with

Also associated with

Rating

Leptospira membrane proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Leptospira membrane proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Leptospira membrane proteins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1718608