C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/20 (2006.01) A61K 31/70 (2006.01) A61K 39/02 (2006.01) A61K 39/40 (2006.01) A61K 48/00 (2006.01) C07K 1/14 (2006.01) C07K 16/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2215900
This invention presents antigenic preparations of Leptospira species outer membrane proteins and their immunogenic fragments which are useful for inducing immune response in animals, e.g., for use as vaccines against diseases caused by leptospirosis. Also presented are methods and kits for diagnosing leptospirosis by detecting the presence of these proteins, their immunogenic fragments, antibodies to these proteins or their fragments, or polynucleotides which encode or are translatable into these proteins or their fragments. Further disclosed are methods for isolating these proteins.
La présente invention concerne des préparations antigéniques de protéines de la membrane extérieure des leptospires et de leurs fragments immunogènes qui conviennent particulièrement à l'induction d'une réaction immune chez les animaux, par exemple en utilisation comme vaccins contre les affections causées par la leptospirose. L'invention concerne également des procédés et des trousses de diagnostics de la leptospirose par détection de la présence de ces protéines, de leurs fragments immunogènes, d'anticorps contre ces protéines ou leurs fragments, ou de polynucléotides codant ces protéines ou leurs fragments ou qui peuvent être traduits en ces protéines ou en leurs fragments. L'invention concerne en outre des procédés d'isolation de ces protéines.
Smart & Biggar
The Regents Of The University Of California
LandOfFree
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