Leucine-based motif and clostridial neurotoxins

Details Leucine-based motif and clostridial neurotoxins Leucine-based motif and clostridial neurotoxins

C - Chemistry, Metallurgy

07

K

C07K 14/33 (2006.01) A61K 38/16 (2006.01) A61P 21/00 (2006.01) A61P 29/02 (2006.01) A61P 37/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2416988

Modified neurotoxin comprising neurotoxin including structural modification, wherein the structural modification alters the biological persistence, such as the biological half-life and/or a biological activity of the modified neurotoxin relative to an identical neurotoxin without the structural modification. In one embodiment, methods of making the modified neurotoxin include using recombinant techniques. In another embodiment, methods of using the modified neurotoxin to treat conditions include treating various disorders, neuromuscular aliments and pain.

L'invention porte sur des neurotoxines modifiées présentant des modifications de structure en altérant la persistance biologique telles que leur demi-vie biologique et/ou leur activité biologique par rapport à une neurotoxine identique sans modification de structure, sur leur procédé de modification recourant à des techniques de recombinaison; et sur leurs modes d'utilisation pour traiter des affections telles que différents troubles dont des troubles neuromusculaires et la douleur.

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