Leukotriene antagonists

Details Leukotriene antagonists Leukotriene antagonists

C - Chemistry, Metallurgy

07

D

167/242, 167/262

C07D 333/04 (2006.01) A61K 31/19 (2006.01) C07C 45/29 (2006.01) C07C 45/44 (2006.01) C07C 45/56 (2006.01) C07C 45/62 (2006.01) C07C 45/67 (2006.01) C07C 45/68 (2006.01) C07C 45/71 (2006.01) C07C 45/72 (2006.01) C07C 47/542 (2006.01) C07C 47/546 (2006.01) C07C 47/548 (2006.01) C07C 47/55 (2006.01) C07C 47/575 (2006.01) C07C 49/86 (2006.01) C07D 333/18 (2006.01)

Patent

CA 1243035

ABSTRACT The compounds represented by the following structural formula (I) Image (I) wherein m is 1 or 2; n is 1, 2 or 3; R' is hydrogen or methyl; R is a radical selected from the group consisting of: Image or Image wherein R1 is C8 to C13 alkyl, C7 to C12 alkoxy, C7 to C12 thioalkyl, C10 to C12 1-alkynyl, 11-dodecynyl, 1-trans-dodecenyl, 5-(4-acetyl-3-hydroxy-2- propylphenoxy)pentoxy, 2(Z),5(Z)-undecadienyloxy, phenyl-C4 to C10 alkyl, phenyl-C3 to C9 alkoxy, trifluoromethyl-C7 to C12 alkyl, cyclohexyl- C4 to C10 alkyl or Image , wherein each q is 0, 1, 2 or 3 but the sum of both q's does not exceed 3, and R2 is hydrogen, bromo, chloro, methyl, trifluoromethyl, hydroxy, methoxy or nitro; or R1 is hydrogen and R2 is C8 to C13 alkyl, C7 to C12 alkoxy, C7 to C12 thioalkyl, C10 to C12 1-alkynyl, 11-dodecynyl, 1-trans-dodecenyl, 5-(4-acetyl-3-hydroxy-2- propylphenoxy)pentoxy, 2(Z),5(Z)-undecadienyloxy, phenyl-C4 to C10 alkyl, phenyl- C3 to C9 alkoxy, trifluoromethyl-C7 to C12 alkyl, cyclohexyl-C4 to C10 alkyl or Image , wherein each q is 0, 1, 2 or 3 but the sum of both q's does not exceed 3, and p is 0 or 1, with the proviso that R is not a thiophene radical and any of R1 and R2 above are not thioalkyl when p is 1; and pharmaceutically acceptable salts thereof have been found to be leukotriene antagonists and useful in the treatment of diseases in which leukotrienes are a factor, such as asthma.

472021

Affiliated with

Also associated with

Rating

Leukotriene antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Leukotriene antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Leukotriene antagonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1298129