Leukotriene antagonists

Details Leukotriene antagonists Leukotriene antagonists

C - Chemistry, Metallurgy

07

D

260/519.1, 260/5

C07D 303/14 (2006.01) C07D 303/40 (2006.01) C07D 307/33 (2006.01)

Patent

CA 1225656

LEUKOTRIENE ANTAGONISTS ABSTRACT OF THE INVENTION The compounds represented by the formula (I) Image (I) wherein m is 0, 1 or 2; p is 9, 10, 11, 12 or 13; R1 is hydrogen, amino or -NH?CH3; R2 is hydroxyl, amino, -NHCH2CO2H, Image , Image , Image or -NHCH2CONH2; and X is -CO2H, -CH2OH or Image with the proviso that when m is 0, R1 is hydrogen, or a pharmaceutically acceptable salt thereof have been found to be leukotriene antagonists and useful in the treatment of diseases in which leukotrienes are a factor, such as asthma.

448870

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