Leukotriene antagonists

Details Leukotriene antagonists Leukotriene antagonists

C - Chemistry, Metallurgy

07

C

260/519.1, 260/5

C07C 149/14 (1985.01)

Patent

CA 1232917

LEUKOTRIENE ANTAGONISTS ABSTRACT OF THE INVENTION The compounds represented by the formula (I) Image (I) wherein n is 1 or 2; m is 0, 1 or 2; p is 9, 10, 11, 12 or 13; X is hydrogen or hydroxyl; R is hydroxyl or amino; R1 is hydrogen, amino or Image ; and R2 is hydroxyl, amino, -NHCH2CO2H, Image , Image , or -NHCH2CONH2 with the proviso that when m is 0, R1 is hydrogen or pharma- ceutically acceptable salts thereof have been found to be leukotriene antagonists and useful in the treatment of diseases in which leukotrienes are a factor, such as asthma.

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