Leukotriene antagonists

Details Leukotriene antagonists Leukotriene antagonists

C - Chemistry, Metallurgy

07

D

167/237, 260/314

C07D 233/54 (2006.01) A61K 31/415 (2006.01) C07D 233/84 (2006.01) C07D 233/90 (2006.01)

Patent

CA 1242732

ABSTRACT OF THE INVENTION The compounds represented by the formulae (I) or (IA): Image (I) CH3(CH2)m - C ? C - Image - Y (IA) wherein m is 9, 10, 11, 12 or 13; W is CH3(CH2)m-, Image C = CH(CH2)9- or phenyl(CH2)8- ; Y is selected from the group consisting of -CO2H, -CH2OH, Image and Image wherein n is 2 or 3 and Z is hydroxyl or hydrogen; and R is selected from the imidazolyl radical of the following formulae (A) or (B) Image (A) wherein R1 is hydrogen, C1 to C4 alkyl or C3 to C4 alkenyl, R2 is hydrogen, C1 to C4 alkyl, carboxyl or carboxamido, or either -(CH2)pCO2H or -(CH2)pCONH2, wherein p is 1 or 2, when R1 and R3 are hydrogen or C1 to C4 alkyl, and R3 is hydrogen, C1 to C4 alkyl or -CH2CO2H with the proviso that R1, R2 and R3 cannot all be hydrogen or (B) Image wherein R4 is hydrogen, C1 to C4 alkyl or C3 to C4 alkenyl, R5 is hydrogen, C1 to C4 alkyl or C3 to C4 alkenyl and R6 is hydrogen or carboxyl with the proviso that R4, R5 and R6 cannot all be hydrogen; or a pharma- ceutically acceptable salt thereof have been found to be leukotriene antagonists and useful in the treatment of diseases in which leukotrienes are a factor, such as asthma.

483865

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