Leukotriene antagonists intermediates

Details Leukotriene antagonists intermediates Leukotriene antagonists intermediates

C - Chemistry, Metallurgy

07

D

260/485.3, 260/5

C07D 303/14 (2006.01) C07D 303/40 (2006.01) C07D 307/33 (2006.01)

Patent

CA 1228864

LEUKOTRIENE ANTAGONISTS INTERMEDIATES ABSTRACT OF THE INVENTION The compounds represented by the formula (I) Image (I) wherein m is 0, 1 or 2; p is 9, 10, 11, 12 or 13; R1' is hydrogen, Image or Image and R2' is amino, -NHCH2CO2R3', Image , Image ', Image , -NHCH2CONH2 or -OR3' wherein R3' is an alkyl radical containing one to six carbon atoms with the proviso that when m is 0, R1' is hydrogen are chemical intermediates in the synthesis of leukotriene antagonists of the formula (II) Image (II) wherein m and p, are described above and Rl is hydrogen, amino or Image ; R2 is hydroxyl, amino, -NHCH2CO2H, Image , Image , Image or -NHCH2CONH2; and X is Image , -CO2H or -CH2OH which are useful in the treatment of diseases in which leukotrienes are a factor, such as asthma.

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