Leukotriene b4 antagonists

Details Leukotriene b4 antagonists Leukotriene b4 antagonists

C - Chemistry, Metallurgy

07

D

C07D 311/66 (2006.01) A61K 31/19 (2006.01) A61K 31/195 (2006.01) A61K 31/215 (2006.01) A61K 31/35 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) C07C 235/60 (2006.01) C07D 295/192 (2006.01) C07D 311/58 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2081766

This invention relates to compounds of formula (I) and the stereoisomers and pharmaceutically acceptable salts thereof, wherein R is alkyl, alkenyl, alkynyl, or cycloalkylalkyl; R1 is alkyl; R2 is hydrogen or alkyl; R6 is alkyl; n is 1 to 5; p is 0 to 6; x is 0 or 2; and R4 and R5 are independently hydrogen or alkyl or together with N form a cycloalkylamine. The compounds of formula (I) are leukotriene B4 antagonists and are useful as anti- inflammatory agents and in treating disease conditions mediated by LTB4.

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