Leukotriene-b4 antagonists, process for producing the same...

Details Leukotriene-b4 antagonists, process for producing the same... Leukotriene-b4 antagonists, process for producing the same...

C - Chemistry, Metallurgy

07

C

C07C 59/68 (2006.01) A61K 31/19 (2006.01) A61K 31/215 (2006.01) A61K 31/44 (2006.01) A61K 31/557 (2006.01) A61K 31/715 (2006.01) C07C 59/90 (2006.01) C07C 65/28 (2006.01) C07C 69/73 (2006.01) C07C 69/738 (2006.01) C07C 69/94 (2006.01) C07C 317/46 (2006.01) C07C 323/62 (2006.01) C07D 213/79 (2006.01) C08B 37/16 (2006.01)

Patent

CA 2091182

ABSTRACT OF THE DISCLOSURE Leukotriene-B4 antagonists have formula (I), in which X represents a CH2 group or an oxygen atom; Y is C1-C4-alkoxy or -S(O)p-(C1-C4)-alkyl; p is 0, 1 or 2; Z can represent a hydrogen atom or the residue A-B-COOH, where A represents a hydroxymethylene group or a carbonyl group and B represents an alkylene group with 1-6 C atoms in the chain or one of the residues illustrated in (a), (b) or (c), provided that A does not represent the residue (d), when X represents a CH2 group, R1 represents the residue OH,-O-(C1-C4)-alkyl, -O-(C3-C6)- cycloalkyl, -O-(C7-C12)-aralkyl or the residue NHR4, where R4 represents hydrogen, (C1-C4)-alkyl; (C3-C6)-cycloalkyl, (C6- C10)-aralkyl; also disclosed are their salts with physiologically tolerable bases and their cyclodextrin clathrates, a process for producing the same and their use as medicinal drugs.

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