Leukotriene b4 receptor transgenic mammals

Details Leukotriene b4 receptor transgenic mammals Leukotriene b4 receptor transgenic mammals

C - Chemistry, Metallurgy

12

N

C12N 15/67 (2006.01) A01K 67/027 (2006.01) C07K 14/705 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2367160

The present invention describes a non-human transgenic mammal that produces in its leukocytes, a recombinant human leukotriene B4 receptor (BLTR), having physiological activity of human BLTR. The transgenic mammal has stably integrated into its genome an exogenous gene construct which includes (A) 5' expression regulating sequences, including a BLTR specific promoter, (B) DNA encoding the BLTR and a signal sequence effective in directing overexpression of the BLTR into leukocytes of the transgenic mammal and (C) 3' regulatory sequences that result in the overexpression of the DNA in the leukocytes. In one embodiment, (A), (B), and (C) are operably linked in the gene construct to obtain production of the BLTR in the leukocytes and overexpression thereof in the transgenic mammal.

Cette invention concerne un mammifère transgénique non humain qui produit, dans ses leucocytes, un récepteur B¿4? de leucotriène humain et recombinant (BLTR) possédant l'activité physiologique d'un BLTR humain. Le génome de ce mammifère transgénique contient une construction génique exogène qui y est intégrée de manière stable et qui comprend: (A) des séquences de régulation d'expression 5', y compris un promoteur spécifique au BLTR; (B) un ADN codant le BLTR et une séquence de signalisation efficace permettant d'orienter la surexpression du BLTR dans les leucocytes du mammifère transgénique; et (C) des séquences régulatrices 3' qui entraînent une surexpression de l'ADN dans les leucocytes. Dans un mode de réalisation, (A), (B) et (C) sont liés fonctionnellement dans la construction génique afin d'entraîner la production de BLTR dans les leucocytes et sa surexpression dans le mammifère transgénique.

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