Levels of bcma protein expression on b cells and use in...

Details Levels of bcma protein expression on b cells and use in... Levels of bcma protein expression on b cells and use in...

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 37/06 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2720682

The present invention provides a method of measuring the levels of BCMA B-cell maturation protein in a biological sample, specifically upon the B cell surface. The diagnostic assays are useful in predicting an individual's likelihood of developing or currently suffering from an autoimmune disease, such as SLE, and for methods for treating an individual clinically diagnosed with an autoimmune disease. This diagnostic test serves to predict a patient's likelihood to respond to a specific drug treatment, in particular treatment with BLyS antagonists, either singly or in combination with other immune suppressive drugs.

La présente invention concerne une méthode permettant de mesurer les niveaux de BCMA dans un échantillon biologique, spécifiquement à la surface des lymphocytes B. Les dosages diagnostiques sont utiles dans la prédiction de la probabilité que présente un patient de développer ou dêtre actuellement atteint dune maladie auto-immune, comme le lupus érythémateux disséminé, et pour des méthodes visant à traiter un individu chez qui une maladie auto-immune a été diagnostiquée. Ce test diagnostic sert à prédire la probabilité que présente un patient de répondre à un traitement médicamenteux spécifique, en particulier à un traitement par antagonistes de BLyS, soit seul, soit en association avec dautres médicaments immunosuppresseurs.

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