Levo-rotary 3-phenoxy morphinan derivatives

C - Chemistry – Metallurgy – 07 – D

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260/237.6

C07D 221/28 (2006.01) C07D 217/18 (2006.01)

Patent

CA 1088935

Abstract There are described levo-rotary 3-phenoxy morphinan derivatives of the general formula Image wherein R is halogen, nitro, lower alkyl, lower alkoxy, hydroxy or hydrogen; R1 is hydrogen, lower alkyl, lower alkenyl, -CH2(CH2)pR2 or -?-(CH2)p-R2; R2 is heteroaro- matic, axomatic or cyclo-lower alkyl; p is an integer from 0 to 3; and n is an integer from 1 to 5 and pharmaceutically acceptable acid addition salts which are useful as analgesic and/or narcotic antagonists.

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