Levodopa prodrugs, and compositions and uses thereof

Details Levodopa prodrugs, and compositions and uses thereof Levodopa prodrugs, and compositions and uses thereof

C - Chemistry, Metallurgy

07

C

C07C 229/36 (2006.01) A61K 31/216 (2006.01) A61K 31/24 (2006.01) A61K 31/4409 (2006.01) A61K 31/455 (2006.01) A61K 31/609 (2006.01) A61K 31/618 (2006.01) A61P 25/16 (2006.01) C07C 235/60 (2006.01) C07D 213/79 (2006.01) C07D 213/80 (2006.01)

Patent

CA 2568632

Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed. Wherein Q is selected from X-CO-, and -CO-X-; X is selected from-O-, and -NR6- ; n is an integer from 2 to 4; R5 is selected from hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, cycloalkyl, substituted cycloalkyl, heteroalkyl, substituted heteroalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, and substituted heteroarylalkyl; and when Q is -X- -CO-, R5 is further selected from alkoxy, substituted alkoxy, cycloalkoxy, and substituted cycloalkoxy.

L'invention a trait à des promédicaments de lévodopa, à des procédés de préparation de promédicaments de lévodopa, à des procédés d'utilisation de promédicaments de lévodopa, et à des compositions à base de promédicaments de lévodopa. Dans la formule (I), Q est sélectionné parmi X-CO- et -CO-X- ; X est sélectionné parmi -O- et -NR?6¿- ; n est un entier compris entre 2 et 4 ; R?5¿ est sélectionné parmi hydrogène, alkyle, alkyle substitué, aryle, aryle substitué, arylalkyle, arylalkyle substitué, cycloalkyle, cycloalkyle substitué, hétéroalkyle, hétéroalkyle substitué, cyclohétéroalkyle, cyclohétéroalkyle substitué, hétéroaryle, hétéroaryle substitué, hétéroarylalkyle et hétéroarylalkyle substitué ; et, lorsque Q représente -X-CO-, R?5¿ est également sélectionné parmi alcoxy, alcoxy substitué, cycloalcoxy, et cycloalcoxy substitué.

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