Levothyroxine compositions and methods

Details Levothyroxine compositions and methods Levothyroxine compositions and methods

A - Human Necessities

61

K

A61K 9/00 (2006.01) A01N 37/12 (2006.01) A01N 37/44 (2006.01) A61K 9/20 (2006.01) A61K 9/38 (2006.01) A61K 9/44 (2006.01) A61K 31/195 (2006.01)

Patent

CA 2440190

The present invention generally relates to stable pharmaceutical compositions, and methods of making and administering such compositions. In one aspect, the invention features stabilized pharmaceutical compositions that include pharmaceutically active ingredients such as levothyroxine (T4) sodium and liothyronine (T3) sodium (thyroid hormone drugs), preferably in an immediate release solid dosage form. Also provided are methods for making and using such immediate release and stabilized compositions.

L'invention concerne d'une manière générale des compositions pharmaceutiques stables et des procédés de fabrication et d'administration de celles-ci. Dans un mode de réalisation, l'invention concerne des compositions pharmaceutiques stabilisées renfermant des principes actifs sur le plan pharmaceutique, tels que la lévothyroxine (T4) sodique et la liothyronine (T3) sodique (médicaments à base d'hormone thyroïdienne), de préférence sous une forme galénique solide à libération immédiate. L'invention concerne également des procédés de fabrication et d'utilisation de ces compositions à libération immédiate et stabilisées.

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