Lewis-type sugar chain derivative

Details Lewis-type sugar chain derivative Lewis-type sugar chain derivative

C - Chemistry, Metallurgy

07

H

C07H 17/02 (2006.01) C07H 3/06 (2006.01)

Patent

CA 2129140

ABSTRACT OF THE DISCLOSURE The object of the present invention is to provide a new SLe-type sugar chain derivative represented by the following formula (I), which is useful as a pharmaceutical and which contains moranoline: Image (I) wherein R1 represents hydrogen, a lower alkyl, a lower alkenyl or a lower alkynyl; R2 and R3 differ from each other and represent a galactosyl, sialylgalactosyl or fucosyl group; R4 represents a hydroxyl group or an acetamido group. The present invention comprises a sugar chain derivative containing a moranoline, and having a new structure. Possessing cell adhesion inhibitory activity, the compounds of the present invention antagonizes selectin, serving well in the treatment of inflammation, inflammation-associated thrombosis, asthma and rheumatism, and in the prevention and treatment of immunological diseases and cancer.

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