Lfa-1 antagonist compounds

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 405/12 (2006.01) A61K 31/34 (2006.01) A61K 31/40 (2006.01) A61K 31/425 (2006.01) A61P 37/06 (2006.01) C07D 207/00 (2006.01) C07D 207/16 (2006.01) C07D 277/00 (2006.01) C07D 307/00 (2006.01) C07D 307/54 (2006.01) C07D 407/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2429353

The invention relates to novel compounds having formula (I), wherein Cy, X, Y, L and R1-6 are as defined herein. The compounds bind CD11/CD18 adhesion receptors such as Lymphocyte Function-associated Antigen-1 (LFA-1) and are therefore useful for treating disorders mediated by LFA-1 such as inflammation

La présente invention concerne des nouveaux composés représentés par la formule (I), dans laquelle Cy, X, Y, L et R1-6 sont tels que définis dans l'invention. Les composés se lient à des récepteurs d'adhésion CD11/CD18, tels que l'antigène LFA-1 et, de ce fait, ils sont utiles pour le traitement de troubles induits par l'antigène LFA-1, telle que l'inflammation et les maladies auto-immunes.

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