Lgmd gene coding for a calcium dependent protease

Details Lgmd gene coding for a calcium dependent protease Lgmd gene coding for a calcium dependent protease

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) A61K 35/12 (2006.01) A61K 38/48 (2006.01) A61K 48/00 (2006.01) C12N 9/64 (2006.01) C12Q 1/37 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2204512

A nucleic acid sequence comprising: 1) the sequence represented in figure 8; or 2) the sequence represented in figure 2; or 3) a part of the sequence of figure 2 with the proviso that it is able to code for a protein having a calcium dependant protease activity involved in a LGMD2; or 4) a sequence derived from a sequence defined in 1), 2) or 3) by substitution, deletion or addition of one or more nucleotides with the proviso that said sequences still codes for said protease.

Séquence nucléotidique comprenant: 1) la séquence représentée par la figure 8; ou 2) la séquence représentée par la figure 2; ou 3) une partie de la séquence de la figure 2 à condition que celle-ci puisse coder pour une protéine possédant une activité protéase dépendante du calcium impliquée dans la maladie de la myopathie des ceintures de type 2 (LGMD2); ou 4) une séquence dérivée d'une séquence définie en 1), 2) ou 3), par substitution, délétion ou addition d'un ou de plusieurs nucléotides, à condition que cette séquence code encore pour ladite protéase.

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