Lgr5 modulators in the treatment of alopecia

Details Lgr5 modulators in the treatment of alopecia Lgr5 modulators in the treatment of alopecia

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2738002

The invention relates to an in vitro method of screening for candidate compounds for the preventive or curative treatment of alopecia, which comprises determining the ability of a compound to modulate the expression or the activity of the LGR5 receptor, and also to the use of modulators of the expression or of the activity of this receptor for treating alopecia. The invention also relates to methods for the diagnosis or prognosis, in vitro, of this disease.

L'invention concerne une méthode in vitro de criblage de composés candidats pour le traitement préventif ou curatif de l'alopécie, comprenant la détermination de la capacité d'un composé à moduler l'expression ou l'activité du récepteur LGR5, ainsi que l'utilisation de modulateurs de l'expression ou de l'activité de ce récepteur pour le traitement de l'alopécie. L'invention concerne aussi des méthodes de diagnostic ou pronostic in vitro de cette pathologie.

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