Lh-rh peptide analogues, their uses and pharmaceutical...

Details Lh-rh peptide analogues, their uses and pharmaceutical... Lh-rh peptide analogues, their uses and pharmaceutical...

C - Chemistry, Metallurgy

07

K

C07K 7/23 (2006.01) A61K 38/09 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2292846

The invention relates to LH-RH peptide analogues with excellent affinity for LH-RH receptors, of formula (I): A1-A2-A3-A4-A5-A6-HAA-A7-Pro-Z in which Z, A1 to A7 are specified in the description and HAA is a non-aromatic hydrophobic amino acid having from 7 to 20 carbon atoms. The invention also relates to the uses of said peptide analogues and to the pharmaceutical compositions containing them.

L'invention concerne des analogues de peptides de LH-RH présentant une excellente affinité pour les récepteurs de LH-RH, selon la formule (I) A1-A2-A3-A4-A5-A6-HAA-A7-Pro-Z, dans laquelle Z, A1 à A7 sont tels que spécifiés dans le descriptif, et HAA représente un acide aminé hydrophobe non aromatique comportant 7 à 20 atomes de carbone. L'invention traite également de l'utilisation de ces analogues de peptides et de compositions pharmaceutiques les contenant.

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