Lhrh antagonists having modified aminoacyl residues at...

Details Lhrh antagonists having modified aminoacyl residues at... Lhrh antagonists having modified aminoacyl residues at...

C - Chemistry, Metallurgy

07

K

C07K 7/23 (2006.01) A61K 38/09 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2136079

2136079 9414841 PCTABS00032 A class of potent LHRH decapeptide antagonists possess N-alkylated aminoacyl residues where the side-chain portion of the residue is a 4-(substituted-amino)phenylalanyl, 4-(substituted-amino)cyclohexylalanyl, or .OMEGA.-(substituted-amino)alkyl group, and additionally the aminoacyl residues at position 5 are N-alkylated on the nitrogen atom of the peptide backbone.

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