G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/566 (2006.01) C07K 1/04 (2006.01) C07K 7/54 (2006.01) G01N 33/15 (2006.01) G01N 33/68 (2006.01) G06F 17/50 (2006.01) G06F 19/00 (2006.01)
Patent
CA 2449631
The present invention is directed to the making of library of conformationally constrained peptides and peptidomimetics including chiral azacrowns for use as conformational templates when complexed with metals for the production of conformationally constrained bioactive peptides for use in elucidation of the binding sites and functional groups on the receptor/peptide ternary complex.
La présente invention concerne la création d'une bibliothèque de peptides et de peptidomimétiques à contrainte conformationnelle comprenant des azacrowns chiraux servant de matrices conformationnelles, lorsqu'ils sont complexés avec des métaux pour la production de peptides bioactifs à contrainte conformationnelle servant à l'élucidation des sites de liaison et des groupes fonctionnels sur le complexe ternaire récepteur/peptide.
Marshall Garland R.
Slomczynska Urszula J.
Metaphore Pharmaceuticals Inc.
Smart & Biggar
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