Libraries of genetic packages comprising novel hc cdr1,...

C - Chemistry – Metallurgy – 40 – B

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C40B 40/02 (2006.01) C40B 40/10 (2006.01) C40B 50/06 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2722409

Provided are compositions and methods for preparing and identifying antibodies having CDR3s that vary in se-quence and in length from very short to very long which in certain embodiments may bind to a carbohydrate moiety or the active site of an enzyme. Libraries coding for antibodies with the CDR3s are also provided. The libraries can be provided by modifying a pre-existing nucleic acid library.

Linvention concerne des compositions et des procédés pour préparer et identifier des anticorps comprenant des CDR3 qui varient en séquence et en longueur, de très court à très long, qui dans certains modes de réalisation, peuvent se lier à un fragment glucide ou au site actif dune enzyme. Des bibliothèques codant des anticorps avec les CDR3 sont également fournies. Les bibliothèques peuvent être fournies en modifiant une bibliothèque dacides nucléiques préexistante.

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