Library from toxin mutants, and methods of using same

Details Library from toxin mutants, and methods of using same Library from toxin mutants, and methods of using same

C - Chemistry, Metallurgy

07

K

C07K 14/245 (2006.01) C12Q 1/18 (2006.01) C40B 30/04 (2006.01) C40B 40/10 (2006.01) G01N 33/566 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2664549

This application relates to libraries of ABx toxin mutants, in which a peptide insert is introduced into the protease-sensitive loop of the A-chain sequence to alter the type of cells to which toxic species are delivered. Said libraries are used in the development of therapeutics targeted against specific cell types.

La présente invention se rapporte à des banques de toxines mutantes Abx comportant un insert peptidique qui a été introduit dans la boucle réagissant à la protéase de la séquence de la chaîne A afin de modifier le type de cellules auquel les espèces toxiques sont délivrées. Ces banques sont utilisées pour le développement d'agents thérapeutiques ciblés dirigés contre des types spécifiques de cellules.

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