C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/52 (2006.01) C07D 313/00 (2006.01) C07H 17/08 (2006.01) C12N 9/10 (2006.01) C12N 15/62 (2006.01) C12P 19/62 (2006.01) C07B 61/00 (2006.01)
Patent
CA 2347128
Genetic engineering of the erythromycin polyketide synthase genes to effect combinatorial alterations of catalytic activities in the biosynthetic pathway can be used to generate a library of macrolides impractical to produce by chemical methods. The library includes examples of analogs with one, two and three altered carbon centers of the polyketide products.
On peut mettre en application le génie génétique des gènes d'érythromycine polycétide synthase afin de réaliser des modifications combinatoires d'activités catalytiques dans la trajectoire biosynthétique dans le but de générer une banque de macrolides difficiles à produire au moyen de procédés chimiques. Cette banque comporte des exemples d'analogues présentant un, deux ou trois centres carbone modifiés des produits de polycétides.
Fetherstonhaugh & Co.
Kosan Biosciences Inc.
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