C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/04 (2006.01) A61K 39/12 (2006.01) C07K 14/08 (2006.01) C12N 7/00 (2006.01) C12N 7/06 (2006.01) C12N 7/08 (2006.01) C12N 15/40 (2006.01)
Patent
CA 2439254
The present invention realtes to live attenuated European PRRS viruses which are attenuated by nucleic acid mutations on specific sties of the viral protein coded by ORF 2, 3 and 5. The invention also pertains to nucleotide sequences coding said viruses, methods of generating such viruses and a pharmaceutical composition comprising said PRRS viruses and teh use of said PRRS virus in the manufacture of a vaccine for the prophylaxis and treatment of PRRSV infections.
L'invention concerne des virus de SDRP européen vivants atténués, qui sont atténués par des mutations d'acide nucléique sur des sites spécifiques de la protéine virale codée par ORF 2, 3 et 5. Cette invention concerne également des séquences de nucléotides codant lesdits virus, des procédés de génération de ces virus et une préparation pharmaceutique comportant lesdits virus SDRP et l'utilisation desdits virus SDRP pour fabriquer un vaccin pour la prophylaxie et le traitement d'infections SDRPV.
Elbers Knut
Pesch Stefan
Schuetz Bettina
Boehringer Ingelheim Vetmedica Gmbh
Fetherstonhaugh & Co.
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