Ligand activated transcriptional regulator proteins

Details Ligand activated transcriptional regulator proteins Ligand activated transcriptional regulator proteins

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 14/72 (2006.01) C07K 19/00 (2006.01) C12N 15/63 (2006.01) C12N 15/86 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2388535

Fusion proteins for use as ligand-dependent transcriptional are provided. The fusion proteins include a nucleotide binding domain operatively linked to a ligand-binding domain. They also can include a transcription regulating domain. The nucleotide binding domain is a zinc-finger peptide that binds to a targeted contiguous nucleotide sequence of from 3 to 18 nucleotides are provided. The fusion proteins are used for gene therapy. Also provided are polynucleotides encoding the fusion proteins, expression vectors, and transfected cells.

L'invention concerne des protéines de fusion s'utilisant comme régulateurs de transcription. Ces protéines de fusion contiennent un domaine de liaison aux nucléotides lié de manière fonctionnelle à un domaine de liaison aux ligands. Elles contiennent également un domaine de régulation de la transcription. Le domaine de liaison aux nucléotides est un peptide à doigts de zinc qui se lie à une séquence nucléotidique contiguë ciblée comprenant entre 3 et 18 nucléotides. Les protéines de fusion de l'invention s'utilisent pour la thérapie génique. L'invention concerne enfin les polynucléotides codant pour lesdites protéines de fusion, les vecteurs d'expression et les cellules transfectées.

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