Ligand binding domains of nuclear receptors in controllable...

Details Ligand binding domains of nuclear receptors in controllable... Ligand binding domains of nuclear receptors in controllable...

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01)

Patent

CA 2700725

The present invention relates to an isolated protein comprising a ligand binding domain of a nuclear receptor in controllable form, a method of producing the same, its use for the identification of a ligand, a test system comprising the isolated protein and a method for screening for a ligand for a nuclear receptor using the test system.

La présente invention concerne une protéine isolée comprenant un domaine de liaison d'un ligand d'un récepteur nucléaire se présentant sous forme contrôlable, son procédé de production, son utilisation en vue de l'identification d'un ligand, un système d'essai comprenant la protéine isolée et un procédé de criblage permettant de rechercher un ligand pour un récepteur nucléaire en utilisant ledit système d'essai.

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