Ligand directed enzyme prodrug therapy

Details Ligand directed enzyme prodrug therapy Ligand directed enzyme prodrug therapy

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 47/48 (2006.01) C07K 14/475 (2006.01) C12N 9/48 (2006.01) C12N 9/96 (2006.01) C12N 15/18 (2006.01) C12N 15/57 (2006.01)

Patent

CA 2243533

The invention provides a two component system for use in association with one another comprising; (a) a ligand fusion protein or conjugate with an enzyme capable of targeting the surface of a cell; and (b) a prodrug which can be converted into an active drug by said enzyme, useful in the treatment of tumours.

L'invention concerne un système à deux composantes destinées à être utilisées en association l'une avec l'autre, ces deux composantes étant: (a) une protéine fusionnée à un ligand ou un conjugué comprenant un enzyme capable de cibler la surface d'une cellule; et (b) un promédicament que l'on peut convertir en un médicament actif à l'aide dudit enzyme, utile dans le traitement des tumeurs.

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