Ligand for forming radiolabeled technetium chelates for use...

Details Ligand for forming radiolabeled technetium chelates for use... Ligand for forming radiolabeled technetium chelates for use...

C - Chemistry, Metallurgy

07

K

530/5.04

C07K 5/08 (2006.01) C07K 5/06 (2006.01) A61K 49/02 (1990.01)

Patent

CA 1317066

ABSTRACT The present divisional application is directed to a ligand that may be reacted with a suitable Tc-99m-pertechnetate salt to form novel Tc-99m compounds (imaging agents incorporating Tc-99m as a radiolabel) having relatively high renal extraction efficiencies useful for conducting renal function imaging procedures. The ligand has the following general formula. Image where X is S or N; and wherein Y is -H or wherein Y is - Image - R2, and wherein y1 is -H2 when X is N, or wherein y1 is -H, or a suitable protective group such as -COCH3, -COC6H5, -CH2NHCOCH3, -COCF3, or -COCH2OH when X is S.

615838

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