C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/705 (2006.01) A61K 31/00 (2006.01) A61K 31/19 (2006.01) A61K 38/17 (2006.01) C12N 15/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2471504
The present invention is related to the G-protein coupled orphan receptor GPR43 and the identification of short chain fatty acids as natural ligands of the receptor. The invention further relates to assays for the identification of agents that modulate GPR43 ligand binding and signalling activity, as well as compositions consisting essentially of an isolated GPR43 polypeptide and an isolated short chain fatty acid. The invention also relates to diagnostic methods and kits that take advantage of the novel interaction of GPR43 with short chain fatty acids.
L'invention concerne le récepteur orphelin GPR43 couplé à une protéine G, et l'identification d'acides gras à chaîne courte en tant que ligands naturels de ce récepteur. L'invention concerne en outre des agents qui modulent la liaison et l'activité de signalisation du ligand de GPR43, ainsi que des compositions comprenant principalement un polypeptide GPR43 isolé et un acide gras à chaîne courte isolé. L'invention concerne également des méthodes diagnostiques et des coffrets mettant à profit cette nouvelle interaction entre GPR43 et les acides gras à chaîne courte.
Brezillon Stephane
Detheux Michel
Lannoy Vincent
Le Poul Emmanuel
Parmentier Marc
Euroscreen S.a.
Smart & Biggar
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