Ligand for the c-kit receptor and methods of use thereof

Details Ligand for the c-kit receptor and methods of use thereof Ligand for the c-kit receptor and methods of use thereof

A - Human Necessities

61

K

A61K 38/19 (2006.01) A61D 19/02 (2006.01) A61K 35/14 (2006.01) A61K 35/28 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) C07K 14/52 (2006.01) C07K 14/53 (2006.01) C07K 14/71 (2006.01) C07K 14/715 (2006.01) C12N 5/02 (2006.01) C12N 5/10 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2133982

A pharmaceutical composition which comprises the c-kit ligand (KL) purified by applicants or produced by applicants' recombinant methods in combination with other hematopoietic factors and a pharmaceutically acceptable carrier is provided as well as methods of treating patients which comprise administering to the patient the pharmaceutical composition of this inven-tion. This invention provides combination therapies using c-kit ligand (KL) and a purified c-kit ligand (KL) polypeptide, or a sol-uble fragment thereof and other hematopoietic factors. It also provides methods and compositions for ex-vivo use of KL alone or in combination therapy. A mutated KL antagonist is also described. Such an antagonist may also be a small molecule. Antisense nucleic acids to KL as therapeutics are also described. Lastly, compositions and methods are described that take advantage of the role of KL in germ cells, mast cells and melanocytes.

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