Ligand for the neu gene product

Details Ligand for the neu gene product Ligand for the neu gene product

C - Chemistry, Metallurgy

07

K

C07K 14/475 (2006.01) A61K 38/18 (2006.01) A61K 47/48 (2006.01) C07K 14/71 (2006.01) G01N 33/567 (2006.01) G01N 33/74 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2079585

A purified proteinaceous substance bindable with p185, the translation product of the neu oncogene is dislcosed. The puri- fied proteinaceous substance may be characterized in that it increases the activity of the tyrosine kinase contained in the neu onc- ogene product but does not increase the activity of tyrosine kinase of epidermal growth factor receptor; induces p185 dimeriza- tion and internalization; affects the growth of cells which express p185 in a dose dependent manner; is heat stable from about 56 °C to about 100 °C; is degradable by protease; and has a molecular weight of from about 7,000 to about 14,000 daltons in its smallest active form as determined by gel filtration and ultrafiltration membrane analysis. Methods of treating a mammal to alter the metabolic state of the mammal by administering the protein proteinaceous substance are also disclosed.

Affiliated with

Also associated with

Rating

Ligand for the neu gene product does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Ligand for the neu gene product, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ligand for the neu gene product will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1859015