Ligand for vascular endothelial growth factor receptor

Details Ligand for vascular endothelial growth factor receptor Ligand for vascular endothelial growth factor receptor

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 31/7088 (2006.01) A61K 38/10 (2006.01) A61K 48/00 (2006.01) C07K 7/08 (2006.01) C07K 14/52 (2006.01) A61K 38/00 (2006.01) C07K 4/12 (2006.01)

Patent

CA 2399022

The present invention relates to compositions comprised of a peptide ligand or derivatives thereof that are capable of specific binding to the high affinity receptor-1 of vascular endothelial growth factor (VEGF) and structure similar receptors. The invention further provides a peptide ligand or derivatives thereof that are capable of inhibiting angiogenesis induced by VEGF. The present invention also provides a method for treatment or diagnosis of disease associated with angiogenesis in a patient in need of therapy comprising administering to the patient an effective amount of the pharmaceutical composition of the present invention and a pharmaceutical acceptable carrier.

L'invention concerne des compositions contenant un ligand peptidique ou des dérivés de celui-ci qui sont capables de se lier spécifiquement au récepteur 1 de grande affinité pour le facteur de croissance endothélial vasculaire (VEGF) et à des récepteurs à structure similaire. L'invention concerne de plus un ligand peptidique ou des dérivés de celui-ci qui sont capables d'inhiber l'angiogenèse induite par VEGF. L'invention concerne aussi une méthode permettant de traiter ou de diagnostiquer une maladie associée à l'angiogenèse chez un patient nécessitant un tel traitement ; cette méthode comprend l'administration au patient d'une quantité efficace de la composition pharmaceutique de l'invention et d'un excipient pharmaceutiquement acceptable.

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