Ligand inhibitors of insulin-like growth factor binding...

Details Ligand inhibitors of insulin-like growth factor binding... Ligand inhibitors of insulin-like growth factor binding...

C - Chemistry, Metallurgy

07

K

C07K 14/65 (2006.01) A61K 38/30 (2006.01) G01N 33/566 (2006.01) G01N 33/74 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2224859

Methods for increasing the level of free, biologically active proteins, including insulin-like growth factors, and for treating IGF-responsive conditions are provided. The methods generally comprise administering one or more ligand inhibitors that inhibit the binding of the protein to one or more insulin-like growth factor binding proteins. Suitable ligand inhibitors include analogs of IGF-I or IGF-II and small molecule inhibitors.

Procédés permettant d'augmenter le niveau des protéines libres biologiquement actives, y compris les facteurs de croissance du type insuline (IGF), et de traiter les états sensibles à l'IGF. Ces procédés consistent généralement à administrer un ou plusieurs inhibiteurs de ligands, qui inhibent la liaison de la protéine à une ou plusieurs protéines de liaison du facteur de croissance du type insuline. Les inhibiteurs de ligands appropriés comprennent les analogues de l'IGF-I ou l'IGF-II et les inhibiteurs moléculaires de petite taille.

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