Ligand polypeptide for the g protein-coupled receptor from...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 38/00 (2006.01) C07K 14/47 (2006.01) C07K 14/72 (2006.01) C07K 16/18 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/52 (2006.01)

Patent

CA 2285628

The present invention relates to the murine-derived ligand polypeptide for the G protein-coupled receptor proteins. The ligand polypeptide or the DNA which codes for the ligand polypeptide can be used for (1) development of medicines such as pituitary function modulators, central nervous system function modulators, and pancreatic function modulators, (2) development of receptor binding assay systems using the expression of recombinant receptor proteins and screening of pharmaceutical candidate compounds, and (3) production of non-human transgenic animals or non-human knockout animals for analyzing a function of the genes.

L'invention porte sur le polypeptide ligand d'origine murine pour les protéines réceptrices couplées à la protéine G. Le polypeptide ligand ou l'ADN qui code ce polypeptide ligand peuvent être utilisés pour (1) la mise au point de médicaments tels que modulateurs de la fonction hypophysaire, modulateurs de la fonction du système nerveux central et modulateurs de la fonction pancréatique, (2) l'élaboration de méthodes pour tester la liaison des récepteurs utilisant l'expression de protéines réceptrices de recombinaison et la sélection de composés pharmaceutiques d'intérêt potentiel et (3) la production d'animaux non humains transgéniques ou d'animaux non humains porteurs de gènes inactivés permettant l'analyse d'une fonction génique.

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