C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/01 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01) C12N 15/861 (2006.01)
Patent
CA 2543200
In accordance with the present invention, there is provided a modified virus ablated of its natural receptors interactions with an unmodified or non- naturally occurring cell, said modified virus comprising a non-native polypeptide, said modified virus having an altered tropism conferred by said non-native peptide, and replicating only in cells that can interact with said non-native peptide, said virus being incapable of infecting a cell through a CAR-dependent entry pathway. There is also provided a modified cell line for replicating the modified virus. These two together can be advantageously put into practice in the field of medicine and more particularly in gene therapy.
L'invention porte sur un virus modifié par ablation de l'interaction de ses récepteurs naturels avec des cellules non modifiées ou de génération non naturelle. Ledit virus: comprend un polypeptide non natif; présente un tropisme altéré conféré par ledit tropisme; ne se réplique que dans des cellules pouvant interagir avec le polypeptide non natif; est incapable d'infecter une cellule par un mécanisme de pénétration dépendant du CAR. L'invention porte également sur une lignée de cellules modifiée de réplication du virus modifié. Ledit virus et ladite lignée peuvent avantageusement trouver des applications médicales et plus particulièrement en thérapie génique.
Massie Bernard
O'connor-Mccourt Maureen
Zeng Yue
National Research Council Of Canada
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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