Ligand-specific inhibition of attachment of immune cells to...

A - Human Necessities – 61 – L

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A61L 31/14 (2006.01)

Patent

CA 2757842

Methods for protecting biomaterials comprise attaching CD47 or Ig domain thereof to the surface of the biomaterial, thereby inhibiting or reducing immune cell attachment and/or immune cell- mediated damage to the biomaterial. Also provided are kits for practicing these methods and the protected biomaterials.

L'invention porte sur des procédés de protection de biomatériaux, qui comprennent la fixation de CD47 ou du domaine Ig de celle-ci à la surface du biomatériau, permettant ainsi d'inhiber ou de réduire la fixation de cellules immunitaires et/ou un dommage facilité par des cellules immunitaires au biomatériau. L'invention porte également des trousses pour la mise en uvre de ces procédés et sur les biomatériaux protégés.

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