Ligand to gpr8 and dna thereof

Details Ligand to gpr8 and dna thereof Ligand to gpr8 and dna thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/711 (2006.01) A61K 38/17 (2006.01) A61P 1/14 (2006.01) A61P 3/04 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 1/21 (2006.01) C12P 21/02 (2006.01) C12P 21/08 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2413195

A ligand to GPR8, its DNA, etc. More particularly speaking, a polypeptide capable of binding to GPR8 or its amide or ester or salts thereof, DNA thereof, etc. are provided. The ligand to GPR8 as described above is useful in developing a receptor-binding assay system with the use of a GPR8 expression system, screening candidate compounds for drugs such as preventives and remedies for obesity, appetite stimulating agents and prolactin production inhibitors, etc.

La présente invention concerne un ligand de GPR8, son ADN, etc., et plus particulièrement un polypeptide capable de se lier à GPR8 ou son amide ou son ester ou ses sels, l'ADN dudit polypeptide, etc. Le ligand de GPR8 décrit ci-dessus est utile pour mettre au point un système d'analyse par liaison au récepteur à l'aide d'un système d'expression de GPR8, et pour cribler des composés candidats pour des médicaments tels que des médicaments de prévention et de traitement de l'obésité, des agents stimulateurs de l'appétit, des inhibiteurs de production de prolactine, etc.

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