Ligands for flt3 receptors

Details Ligands for flt3 receptors Ligands for flt3 receptors

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A01K 67/027 (2006.01) A61K 35/12 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) A61K 48/00 (2006.01) C07K 14/475 (2006.01) C07K 16/22 (2006.01) C12N 5/00 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2162397

Ligands for flt3 receptors capable of transducing self renewal signals to regulate the growth, proliferation or differentiation of progenitor cells and stem cells are disclosed. The invention is directed to flt3-L as an isolated protein, the DNA encoding the Flt3-L, host cells transfected with cDNAs encoding flt3-L, compositions comprising flt3-L, methods of improving gene transfer to a mammal using flt3-L, and methods of improving transplantations using flt3-L. Flt3-L finds use in treating patients with anemia, AIDS and various cancels.

On décrit des ligands pour des récepteurs flt3 capables d'effectuer la transduction de signaux d'auto-renouvellement pour réguler la croissance, la prolifération ou la différenciation de cellules progénitrices et de cellules souches. L'invention concerne le flt3-L en tant que protéine isolée, l'ADN codant le flt3-L, les cellules hôtes ayant subi une transfection avec l'ADN-c codant le flt3-L, des compositions contenant le flt3-L, des procédés pour améliorer le transfert des gènes à un mammifère utilisant le flt3-L et des procédés améliorant les transplantations utilisant le flt3-L. Le flt3-L est utile pour traiter les patients atteints d'anémie, du SIDA et de différents cancers.

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