C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/00 (2006.01) A61K 51/04 (2006.01) A61K 51/08 (2006.01) C07B 59/00 (2006.01) C07D 213/40 (2006.01) C07D 213/64 (2006.01) C07D 213/68 (2006.01) C07F 13/00 (2006.01) C07K 14/655 (2006.01) C07K 14/815 (2006.01) A61K 43/00 (1990.01) A61K 49/02 (1990.01)
Patent
CA 2129036
2129036 9315771 PCTABS00024 Amide-thiolate ligands having improved metal chelate formation kinetics are disclosed. The ligands include an amine to facilitate rapid formation of an amine-amide-thiolate intermediate complex, followed by transfer of the metal to or conversion of the ligand to a thermodynamically stable amide-thiolate complex. In one embodiment of the invention, the amine is a tertiary amine, or its equivalent, strategically located to facilitate complex formation. In another embodiment of the invention, the amine is part of pyridine containing a lower alkoxy substituent in the 2 or 4 ring position. O-dealkylation occurs upon complexation causing the amine to become a vinylogous amide as part of a thermodynamically stable amide-thiolate complex. The amide-thiolate ligands of the present invention may be used for post formed labeling of biological substances for use in the fields of diagnosis and therapy.
Biosynthema Inc.
Gowling Lafleur Henderson Llp
LandOfFree
Ligands for improving metal chelate formation kinetics does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Ligands for improving metal chelate formation kinetics, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ligands for improving metal chelate formation kinetics will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1847554