C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/14 (2006.01) A61K 31/55 (2006.01) A61K 31/5513 (2006.01) A61K 45/06 (2006.01) A61P 9/00 (2006.01) A61P 17/00 (2006.01) A61P 19/00 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) C07D 263/48 (2006.01) C07D 277/08 (2006.01) C07D 307/68 (2006.01) C07D 333/38 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07K 5/023 (2006.01)
Patent
CA 2411549
The invention relates to the use of cyclic compounds as ligands of integrin receptors, in particular as ligands of the .alpha.v.szlig.3 integrin receptor. The invention also relates to the novel compounds, to the use thereof and to pharmaceutical preparations which contain said compounds. Examples of said compounds include benzazepines, benzodiazepines and thieno[3,2-b]azepines, used for treating arteriosclerosis, rheumatoid arthritis, restenosis after vessel damage or stent implantation, angioplasty, acute kidney failure, microangiopathy associated with angiogenesis, diabetic angiopathy, thrombocyte- mediated vascular occlusion, arterial thrombosis, congestive heart-failure, myocardial infarct, apoplexy, cancer, osteoporosis, hypertension, psoriasis or viral, parasitic or bacterial diseases, inflammation, wound healing, hyperparathyroidism, Paget's bone disease, malignant hypercalcemia, or metastatic osteolytic lesions.
L'invention concerne l'utilisation de composés cycliques en tant que ligands de récepteurs d'intégrine, en particulier en tant que ligands du récepteur d'intégrine .alpha.¿v?.szlig.¿3?. L'invention concerne également lesdits composés, leur utilisation, ainsi que des préparations pharmaceutiques contenant ces composés
Geneste Herve
Graef Claudia Isabella
Hornberger Wilfried
Kling Andreas
Lange Udo
Basf Ag
Robic
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